首页> 外国专利> A POLYVALENT COMBINED IMMUNISING AND/OR THERAPEUTIC PREPARATION FOR USE IN BACTERIAL INFECTIONS OR FOOD POISONING, PARTICULARLY SALMONELLOSIS, A METHOD FOR PRODUCTION OF THIS PREPARATION, ITS USE AND A VACCINE COMPRISING THIS PREPARATION

A POLYVALENT COMBINED IMMUNISING AND/OR THERAPEUTIC PREPARATION FOR USE IN BACTERIAL INFECTIONS OR FOOD POISONING, PARTICULARLY SALMONELLOSIS, A METHOD FOR PRODUCTION OF THIS PREPARATION, ITS USE AND A VACCINE COMPRISING THIS PREPARATION

机译:用于细菌感染或食物中毒的多价免疫和/或治疗组合疗法,特别是沙门氏菌病,制备方法,制备方法和疫苗以及包含该制备方法的疫苗

摘要

The invention relates to a polyvalent, combined immunising and/or therapeutic preparation for use in bacterial infections and food poisoning, particularly salmonellosis, comprising inactivated Salmonella sp. strain with antibodies bound thereto, characterized in that the said antibodies are selected so as to bind to the antigenic epitopes in structures of repeating O- specific units in the basic groups of Salmonella bacteria, which are responsible for the principle of reaction with the host immune system, while not blocking the epitopes responsible for the recognition of Salmonella serotype, wherein the inactivated bacteria are bacteria of the Salmonella genus enterica species, subspecies: enterica, salamae, arizonae and/or diarizonae, houtenae, Indica. The invention relates also to a method for production of this polyvalent, combined immunising and/or therapeutic preparation and a vaccine against salmonelloses comprising said preparation.
机译:本发明涉及用于细菌感染和食物中毒特别是沙门氏菌病的多价,联合免疫和/或治疗制剂,其包含灭活的沙门氏菌。具有与其结合的抗体的菌株,其特征在于,选择所述抗体以便与沙门氏菌基本组中重复的O-特异性单元的结构中的抗原表位结合,所述表位负责与宿主免疫反应的原理。该系统是在不阻断负责识别沙门氏菌血清型的表位的同时,其中灭活的细菌是肠沙门氏菌属的细菌,亚种:肠,沙门氏菌,亚利桑那和/或二arizonae,houtenae,In。本发明还涉及生产该多价,组合的免疫和/或治疗制剂的方法以及包含所述制剂的沙门氏菌疫苗。

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