HIGH OXYGEN PERMEABILITY MATERIAL BASED ON MARINE BIOLOGICAL SUBSTANCES AND PREPARATION METHOD AND USE THEREOF

摘要

The present invention discloses a material with high oxygen permeability based on marine biological substance, which is obtained by compounding a silicon-containing substance with silicon-oxy group and a bioactive substance selected from one or more of alginic acid, collagen, hyaluronic acid and salt thereof, in the presence of a crosslinking agent. The present invention also discloses a preparation method for the material with high oxygen permeability, including: the silicon-containing substance and bioactive substance are mixed under acidic condition, and then the mixture is subjected to crosslinking reaction in the presence of a crosslinking agent. The present invention also discloses use of the material with high oxygen permeability or method thereof in preparation of corneal contact lens, corneal scaffold material or corneal substitute. The present invention obtains a material with high oxygen permeability that can satisfy the requirement of high oxygen permeability for extended wear and show good wearing comfort. Furthermore, the employing of marine biological substance with good biocompatibility makes the material with high oxygen permeability have good biocompatibility and high safety performance.