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BLOOD-BRAIN BARRIER-PENETRANT DOPAMINE-B-HYDROXYLASE INHIBITORS

机译:血脑屏障渗透剂多巴胺-B-羟化酶抑制剂

摘要

This invention relates to: (a) compounds of Formula Ia (with R1, R4, R5, R6, n and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-β-hydroxylase inhibitors; (b) pharmaceutical compositions comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.
机译:本发明涉及:(a)用作多巴胺-β-羟化酶抑制剂的式Ia化合物(具有本文所定义的R 1,R 4,R 5,R 6,n和A)及其药学上可接受的盐或溶剂化物; (b)包含此类化合物,盐或溶剂化物的药物组合物; (c)这类化合物,盐或溶剂化物在治疗中的用途; (d)使用此类化合物,盐或溶剂化物的治疗方法; (e)可用于合成此类化合物的方法和中间体。

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