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METHOD FOR DETERMINING A CONCENTRATION OF A TARGET ANALYTE IN A SAMPLE OF BODILY FLUID
METHOD FOR DETERMINING A CONCENTRATION OF A TARGET ANALYTE IN A SAMPLE OF BODILY FLUID
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机译:测定体液样品中目标分析物浓度的方法
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摘要
A method and an apparatus for determining a concentration of a target analyte in a sample of bodily fluid are disclosed. The method involves providing a sample of bodily fluid including the target analyte, providing an internal standard solution including a mixture of components having a plurality of isotopes of the target analyte, wherein a concentration of each isotope is unknown, adding the internal standard solution to the sample, analyzing the sample including the internal standard solution using a mass spectrometer, creating a sample function curve based on signal intensities, wherein the signal intensities define arbitrary units, transferring an analyte signal into a corresponding arbitrary analyte unit by means of the sample function curve, and transferring the arbitrary analyte unit into the concentration of a target analyte by means of a standardization function representing a curve of concentrations depending on the arbitrary units.
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