A novel recombinant adeno-associated virus capsid that is resistant to existing human neutralizing antibodies

摘要

The present invention is a mutant AAV capsid polypeptide that has enhanced neutralizing properties, improved in human liver tissue or hepatocytes (ie, human hepatocytes) or both compared to the non-mutated parent capsid polypeptide. The mutant capsid polypeptide exhibits transduction and / or tropism. [Selection] Figure 1