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Recombinant adeno-associated virus capsids resistant to pre-existing human neutralizing antibodies
Recombinant adeno-associated virus capsids resistant to pre-existing human neutralizing antibodies
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机译:重组腺相关病毒衣壳对已存在的人类中和抗体具有抗性
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摘要
The present invention relates to variant AAV capsid polypeptides, wherein the variant capsid polypeptides exhibit an enhanced neutralization profile, increased transduction and/or tropism in human liver tissue or hepatocyte cells (i.e., human hepatocyte cells), or both, as compared non-variant parent capsid polypeptides.
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