PDGF AND VEGF BINDING APTAMERS AND THEIR USE IN TREATING PDGF AND VEGF MEDIATED CONDITIONS

摘要

To provide aptamers useful for preventing and treating disorders in which PDGF and/or VEGF has been implicated.SOLUTION: An aptamer comprises a sequence: 5'-NZVSLnS'V'ZACNNmGCGZZZAZAGCG-3' (SEQ ID NO: 500), wherein V is selected from an A, C or G; V' is selected from a C, G or Z, wherein V' is complementary to V; S and S' are independently selected from a C or G, wherein S and S' are complementary to each other; each N is independently selected from any naturally occurring or modified nucleotide; each Z is independently selected from a modified pyrimidine; L is selected from any naturally occurring or modified nucleotide, a hydrocarbon linker, a polyethylene glycol linker or a spacer selected from combinations thereof; n is 0 to 20; and m is 0 to 20; and wherein one or more nucleotide insertions are optionally included, as needed.SELECTED DRAWING: Figure 1-1