Method of producing porous base made of bioabsorbable polymer containing heparin, porous base made of bioabsorbable polymer containing heparin, and artificial blood vessel

摘要

The present invention provides a simple method for producing a porous substrate made of a bioresorbable polymer containing heparin without using a surfactant, a porous substrate made of a bioresorbable polymer containing heparin, And, it aims at providing an artificial blood vessel. The present invention is a bioabsorbable polymer, heparin, a solvent 1 which is a poor solvent having low solubility in the bioabsorbable polymer, and a good solvent having high solubility in the bioabsorbable polymer. And, using the solvent 2 incompatible with the solvent 1 and the cosolvent 3 compatible with the solvent 1 and the solvent 2, the heparin is uniformly dispersed, and the bioabsorbable polymer is dissolved. A solution preparing step of preparing a heparin-bioabsorbable polymer solution, and a precipitation step of cooling the heparin-bioabsorbable polymer solution to precipitate a porous body made of heparin-containing bioabsorbable polymer A porous group comprising a heparin-containing bioabsorbable polymer having a freeze-drying step of freeze-drying the porous body consisting of the heparin-containing bioabsorbable polymer to obtain a heparin-containing porous substrate How to manufacture materials It is.