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SIGNALING-BIASED MU OPIOID RECEPTOR AGONISTS
SIGNALING-BIASED MU OPIOID RECEPTOR AGONISTS
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机译:信号偏置MU阿片受体激动剂
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摘要
The invention provides—opioid receptor agonists that are analgesic agents and that promote diminished side effects relative to a comparably effective dose of morphine. The side effects that are absent or attenuated include one or more of the following: constipation, respiratory depression, tolerance, dependence, nausea, confusion, sedation, hypotension, and post-treatment withdrawal symptoms.
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