首页> 外国专利> TREATMENT OF DISEASES BY LIVER EXPRESSION OF AN ENZYME WHICH HAS A DEOXYRIBONUCLEASE (DNase) ACTIVITY

TREATMENT OF DISEASES BY LIVER EXPRESSION OF AN ENZYME WHICH HAS A DEOXYRIBONUCLEASE (DNase) ACTIVITY

机译：肝脏脱氧核糖核酸酶（DNase）活性的肝脏表达治疗疾病

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摘要

The invention relates to the liver-specific delivery and/or expression of an enzyme which has a deoxyribonuclease (DNase) activity for enhanced clearance of cell free DNA (cfDNA) accumulated in hepatic porto-sinusoidal circulation and the use of such liver-specific delivery and/or expression for treatment of various diseases and conditions, including cancer and neurodegeneration.

机译：本发明涉及具有脱氧核糖核酸酶（DNase）活性以增强清除肝门-正弦循环中积累的无细胞DNA（cfDNA）的酶的肝特异性递送和/或表达，以及这种肝特异性递送的用途。和/或表达，用于治疗各种疾病和状况，包括癌症和神经变性。

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公开/公告号US2019241908A1

专利类型
公开/公告日2019-08-08

原文格式PDF
申请/专利权人 CLS THERAPEUTICS LIMITED;
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申请/专利号US201916248245
发明设计人 DMITRY DMITRIEVICH GENKIN;GEORGY VIKTOROVICH TETS;VIKTOR VENIAMINOVICH TETS;
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申请日2019-01-15
分类号C12N15/86;C12N9/22;A61K48;A61K38/46;A61P1/16;A61P35/04;A61P25/28;
国家 US
入库时间 2022-08-21 12:06:37

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