Treatment of diseases by liver expression of enzymes having deoxyribonuclease (DNASE) activity

摘要

The present invention is a liver-specific delivery of an enzyme having deoxyribonuclease (DNase) activity for the enhanced removal of cell-free DNA (DNase) accumulated in the hepatic porto-sinusoidal circulation. And/or expression and/or the use of such liver-specific delivery and/or expression for the treatment of various diseases and conditions, including cancer and neurodegeneration.