anti-cxcr4 antibodies and antibody-drug conjugates, use and methods of producing them, pharmaceutical composition, isolated polynucleotide, vector and isolated host cell

摘要

The present invention relates to antibodies and related molecules that bind to chemokine receptor 4 (cxcr4). The invention further provides antibody-drug conjugates comprising such antibodies, antibody-encoding nucleic acids, vector comprising such nucleic acids, recombinant-producing host cell such antibodies, and methods for obtaining such antibodies. The invention further relates to the use of such antibodies and anti-cxcr4 antibody-drug conjugates for the manufacture of a medicament for the treatment of a disorder associated with the function or expression of cxcr4 (e.g. cancer), such as cancer of cancer. colon, rcc, esophagus, gastric, head and neck, lung, ovarian, pancreatic or hematologic cancers.