method for acid synthesis, and methods for preparing a metal dota chelate and meglumine gadoterate.

摘要

The present invention provides methods for the preparation of compounds useful in therapeutic and in vivo diagnostic applications. In particular, the present invention provides a method for the synthesis of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (dota) and also methods for the preparation of metal chelates. of dota.