Methods for the synthesis of novel chiral ligands, metal chelates, various unnatural amino acids,

摘要

The present invention discloses a process for the synthesis of novel chiral ligands, metal chelates, various unnatural amino acids, marabarox and key intermediates thereof, and the present invention relates to a process for the synthesis of (R) -2-methylproline as starting material, (S) -β ³ -amino acid by induction of asymmetric cleavage with a nickel chelate and by synthesizing marabalix with (S) -3-amino-3-phenylpropionic acid as a core intermediate, yield was high and ee value Was more than 98.2%. In the method of the present invention, the source of the raw material is wide, the conditions of the synthetic process are mild and easy to control, and the optical purity of the product is high.