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Ways of dosage of prolonged release of pregabalin
Ways of dosage of prolonged release of pregabalin
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机译:普瑞巴林延长释放的剂量方式
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摘要
This invention refers to long -release pharmaceutical compositions comprising pregabalin or a salt thereof, which are adapted to release the active ingredient pregabalin according to a double release profile. The formulations comprise two components, the first (fast ER) providing long -term release of the active ingredient in a short controlled mode for about four to six hours,And the second (slow or maintenance) providing prolonged release of the active ingredient over a 24 -hour period. The proportion of each component in the formulation can be adjusted to achieve the AUC and therapeutic effect desired after oral administration to a subject. The invention also refers to methods of using pharmaceutical compositions to treat conditions and disorders that respond to treatment with pregabalin, such a s neuropathic pain associated with peripheral diabetic neuropathy (dpn),Post -herpetic neuralgia (phn),Epilepsy, seizures, fibromyalgia.
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