INFLUENCE OF MICROENCAPSULATION PROCESS PARAMETERS ON NALTREXONE PROLONGED-RELEASE DOSAGE FORM

摘要

The quality parameters of naltrexone microspheres based on the copolymer of lactic and glycolic acids (PLGA) were established as a function of the microencapsulation process parameters. The release profile of the developed naltrexone dosage form was found to coincide with that of the reference drug Vivitrol. The re-sults were interesting scientifically and could be used to develop technology for producing generic Vivitrol.