High dosage of a fixed combination oxycodone/naloxone prolonged release: efficacy and tolerability in patients with chronic cancer pain

Amato Francesco; Ceniti Silvia; Mameli Sergio; Pisanu Giovanni M.; Vellucci Renato; Palmieri Vincenzo; Consoletti Leonardo; Magaldi Dorotea; Notaro Paolo; Marcassa Claudio

首页> 外文期刊>Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer >High dosage of a fixed combination oxycodone/naloxone prolonged release: efficacy and tolerability in patients with chronic cancer pain

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High dosage of a fixed combination oxycodone/naloxone prolonged release: efficacy and tolerability in patients with chronic cancer pain

机译：固定组合的高剂量羟考酮/纳洛酮延长释放：慢性癌疼痛患者的疗效和耐受性

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Opioids are associated with side effects in the treatment of moderate-to-severe chronic cancer pain. Oral combination of opioid agonist-antagonist oxycodone-naloxone (OXN-PR) attenuates gastrointestinal side effects; however, evidence on high-dose OXN-PR treatment is scant. This study evaluates the efficacy and tolerability of high-dose OXN-PR in chronic cancer pain.

机译：阿片类药物与治疗中度至严重的慢性癌痛的副作用有关。阿片类Agonist-拮抗剂羟考酮 - 纳洛酮（OXN-PR）的口服组合衰减胃肠道副作用; 然而，关于高剂量牛粪治疗的证据是味道。本研究评估了高剂量牛粪在慢性癌痛中的疗效和耐受性。

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来源
《Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer 》 |2017年第10期| 共8页
作者
Amato Francesco; Ceniti Silvia; Mameli Sergio; Pisanu Giovanni M.; Vellucci Renato; Palmieri Vincenzo; Consoletti Leonardo; Magaldi Dorotea; Notaro Paolo; Marcassa Claudio;
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作者单位

Azienda Osped Cosenza UOC Terapia Dolore &

Cure Palliat Via Luigi Sturzo 1 Rogliano CS Italy;

Azienda Osped Cosenza UOC Terapia Dolore &

Cure Palliat Via Luigi Sturzo 1 Rogliano CS Italy;

Azienda Osped Cagliari UO Terapia Dolore Cagliari Italy;

Azienda Osped Cagliari UO Terapia Dolore Cagliari Italy;

Azienda Osped Careggi UO Terapia Dolore Florence Italy;

Azienda Osped Benevento UO Terapia Dolore Benevento Italy;

Azienda Osped Riuniti Foggia UO Terapia Dolore Foggia Italy;

Azienda Osped Piove Sacco UO Terapia Dolore &

Cure Palliat Padua Italy;

Azienda Osped Niguarda UO Terapia Dolore Milan Italy;

Ist Clin &

Sci Maugeri Veruno Italy;

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原文格式 PDF
正文语种 eng
中图分类护理学 ;
关键词
Cancer pain; Opioids; Oxycodone; Naloxone; Prolonged release; Constipation; Pain control;

机译：癌症疼痛;阿片类化合物;羟考酮;纳洛酮;长期释放;便秘;疼痛控制;

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1. 羟考酮/纳洛酮控释片与羟考酮控释片治疗韩国癌性疼痛患者的疗效及安全性的随机对照研究 [J] . Kyung-He Lee, Min Kyoung Kim, Yong Sang Hong, 癌症（英文版） . 2018 ,第005期
2. High dosage of a fixed combination oxycodone/naloxone prolonged release: efficacy and tolerability in patients with chronic cancer pain [J] . Amato Francesco, Ceniti Silvia, Mameli Sergio, Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer . 2017 ,第10期

机译：固定组合的高剂量羟考酮/纳洛酮延长释放：慢性癌疼痛患者的疗效和耐受性
3. Opioid-Induced Constipation Relief From Fixed-Ratio Combination Prolonged-Release Oxycodone/Naloxone Compared With Oxycodone and Morphine for Chronic Nonmalignant Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials [J] . Lang Huang, Jian-Guo Zhou, Yu Zhang, Journal of pain and symptom management. . 2017 ,第5期

机译：与羟考酮和慢性非血管疼痛的羟考酮和吗啡相比，来自定义组合的阿片类药物诱导的便秘释放延长释放的羟氢酮/纳洛酮：随机对照试验的系统评价和荟萃分析
4. Efficacy and safety profile of prolonged release oxycodone in combination with naloxone (OXN PR) in Parkinson's disease patients with chronic pain [J] . Madeo Graziella, Schirinzi Tommaso, Natoli Silvia, Journal of neurology . 2015 ,第9期

机译：缓释羟考酮联合纳洛酮（OXN PR）在帕金森氏病慢性疼痛患者中的疗效和安全性
5. Therapy of Patients with Chronic Immune Thrombocytopenic Purpura (ITP): Efficacy, Tolerability, and Safety of a New Nanofiltered Intravenous Immunoglobulin [C] . H.-H. Wolf, S. Davies, G. Smith, European Haematology Association . 2002

机译：慢性免疫血小板减少症患者的治疗患者（ITP）：一种新的纳米过滤静脉内免疫球蛋白的疗效，耐受性和安全性
6. The efficacy of fixed-role therapy with three chronic pain patients. [D] . Josephs, Edward Benson. 1990

机译：固定角色疗法对三位慢性疼痛患者的疗效。
7. Long-term efficacy and safety of oxycodone–naloxone prolonged release in geriatric patients with moderate-to-severe chronic noncancer pain: a 52-week open-label extension phase study [O] . Fabio Guerriero, Anna Roberto, Maria Teresa Greco, 2016

机译：羟考酮-纳洛酮延长释放在中度至重度慢性非癌性疼痛老年患者中的长期疗效和安全性：一项为期52周的开放标签延伸研究
8. Efficacy and safety profile of prolonged release oxycodone in combination with naloxone (OXN PR) in Parkinson’s disease patients with chronic pain [O] . Madeo G, Schirinzi T, Natoli S, 2015

机译：缓释羟考酮联合纳洛酮（OXN PR）在帕金森氏病慢性疼痛患者中的疗效和安全性

High dosage of a fixed combination oxycodone/naloxone prolonged release: efficacy and tolerability in patients with chronic cancer pain

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