MONOCLONAL ISOLATED HUMAN ANTIBODY, COMPOSITION, IMMUNOCUATED, BISPECIFIC OR MULTI-SPECIFIC DIAGNOSTIC METHODS AND METHODS FOR DETECTION OF THE PRESENCE OF CD25 ANTIGEN OR EXPRESSION OF CD25, EXPRESSING AND CELL EXPRESSING,

摘要

"isolated human antibody, hybridoma, transfectoma, eukaryotic or prokaryotic host cell, nonhuman animal or transgenic plant, method for producing a human monoclonal antibody, composition, immunoconjugate, bispecific or multispecific molecule, method for inhibiting the development and / or proliferation of a cd25 expressing cell, method for eliminating a cd25 expressing cell, method for treating or preventing a disorder involving cd25 expressing cells, method and diagnostic kit for detecting the presence of cd25 antigen or a cd25 expressing cell, vector expression, anti-idiotypic antibody, and use thereof ". Isolated human monoclonal antibodies that bind to and inhibit human cd25 and compositions based on related antibodies and molecules are disclosed. Human antibodies may be produced by a hybridoma, a transfectome or in a non-human transgenic animal, for example a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies undergoing v-d-j recombination and isotype change. Also disclosed are pharmaceutical compositions comprising human antibodies, non-human transgenic animals, hybridomas and transfectomas producing human antibodies, and therapeutic and diagnostic methods for using human antibodies.