IN VITRO METHOD FOR DETECTION OF THE PRESENCE OF A PSCA POLYNUCLEOTIDE IN A SAMPLE DERIVED FROM AN INDIVIDUAL AS A CANCER PRESENCE INDICATOR

摘要

"Prostate Stem Cell Antigen Variants (Psca) and Subsequences thereof". psca and its encoded protein and variants thereof are described, wherein psca exhibits tissue-specific expression in normal adult tissue and is abnormally expressed in cancers listed in table i. consequently, psca provides a diagnostic, prognostic, prophylactic and / or therapeutic target for cancer. the psca gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, may be used to stimulate a humoral or cellular immune response; Psca-reactive antibodies or T cells can be used in passive or active immunization.