N-{3-3-CYCLOPROPYL-5-(2-FLUORO-4-IODOPHENYLAMINO)-6,8-DIMETHYL- 2,4,7-TRIOXO-3,4,6,7-TETRAHYDRO-2H-PYRIDO4,3-DPYRIMIDIN-1-YL- PHENYL}-CYCLOPROPANECARBOXAMIDE DIMETHYL SULPHOXIDE SOLVATE AS AN MEK1/2 INHIBITOR.

摘要

The aim of the present invention is to create novel MEK1, MEK2 and MEK1/2 inhibitors which have lower toxicity in long-term dosage. This aim is achieved by the novel compound N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl -2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl] -phenyl}-cyclopropanecarboxamide dimethyl sulphoxide solvate of formula 1.