Immediate-release pharmaceutical compositions comprising oxycodone and naloxone

摘要

Pharmaceutical composition of immediate oral release comprising at least oxycodone or a pharmaceutically acceptable salt thereof and naloxone or a pharmaceutically acceptable salt thereof in a 2: 1 ratio (oxycodone or a pharmaceutically acceptable salt of the same naloxone or a pharmaceutically acceptable salt acceptable thereof) by weight, in which the formulation is released in vitro, when measured using the Farm's pallet method. Eur. At 100 rpm in 0.1 N hydrochloric acid at 37 ° C and using UV detection at 230 nm, = 75% oxycodone or a pharmaceutically acceptable salt thereof by weight and = 75% naloxone or a pharmaceutically acceptable salt of it by weight at 45 min.