Extended release oral Pharmaceutical composition comprising a material extended release, and oxycodone and naloxoneThe pharmaceutical composition stored in conditions of stress is less than 4 for related substances with oxycodone and naloxone; and use of a Binder for making such a composition.

摘要

The present invention relates to storage stable prolonged release pharmaceutical dosage forms comprising oxycodone or a pharmaceutically acceptable salt thereof and naloxone or a pharmaceutically acceptable salt thereof, the manufacture thereof as well as their use for administration to human beings.