Examination of Dissolution Characteristic of Four Bioequivalent Diclofenac Sodium 100 mg Extended Release Formulations under Conditions of Biorelevant Stresses.

摘要

The dissolution characteristics of four extended release (ER) 100 mg diclofenac sodium tablets were examined. The investigations were performed in the paddle apparatus and in the biorelevant dissolution stress test device. The tests yielded striking differences in the dissolution profiles among the products.