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DOUBLE COMPOSITE TABLET FOR ORAL ADMINISTRATION CONTAINING TRAMADOL AND CELECOXIB
DOUBLE COMPOSITE TABLET FOR ORAL ADMINISTRATION CONTAINING TRAMADOL AND CELECOXIB
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机译:含曲马多和塞来昔布的口服复合双片
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摘要
The present invention relates to a double composite tablet for oral administration, comprising: a sustained release layer containing tramadol as an active ingredient; and an immediate release layer containing celecoxib as an active ingredient, wherein the double composite tablet is an oral preparation that is prescribed for alleviation of symptoms or signs of osteoarthritis (degenerative arthritis), alleviation of symptoms or sings of rheumatoid arthritis, alleviation of symptoms or signs of ankylosing spondylitis, relief of acute pain in adults (post-operative or post-extraction pain), primary dysmenorrhea, or severe and moderate acute or chronic pain. Through the present invention, a composition for pain treatment can be provided that reduces side effects of tramadol and has a continuous pain-killing effect for 12 hours by sustainedly releasing tramadol with solubility in water and immediately releasing celecoxib with poor solubility. Furthermore, the number of drugs administered is decreased by preparing two kinds of drugs into a single complex preparation, thereby improving the convenience of drug administration.
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