Double composite tablet for oral administration including tramadol and celecoxib

摘要

The present invention is to alleviate the symptoms or signs of osteoarthritis (degenerative arthritis), alleviate the symptoms and signs of rheumatoid arthritis, alleviate the symptoms and signs of ankylosing spondylitis, acute pain relief (after surgery, pain after extraction), primary dysmenorrhea, An oral preparation prescribed for severe and moderate acute pain, comprising: a sustained release layer containing tramadol as an active ingredient; And it relates to a dual complex tablet for oral administration comprising a rapid release layer containing celecoxib as an active ingredient. Through the present invention, it is possible to provide a composition for treating pain having a sustained analgesic effect for 12 hours while reducing the side effects of tramadol by releasing the water-soluble tramadol and releasing the poorly soluble celecoxib. By preparing a combination product, the number of medications can be reduced to increase the convenience of taking.