PHARMACEUTICAL COMPOSITION COMPRISING MESENCHYMAL STEM CELL EXPRESSING TRAIL AND CD AS EFFECTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER

摘要

The present invention relates to a pharmaceutical composition comprising mesenchymal stem cells expressing TRAIL and CD as an effective ingredient for prevention or treatment of cancer. A pharmaceutical composition comprising TRAIL- and CD-expressing mesenchymal stem cells as an effective ingredient for prevention or treatment of cancer according to the present invention induces cancer cells to undergo apoptosis, thereby inhibiting cancer cell formation and metastasis. In addition, as immortalized mesenchymal stem cells that have a high cell proliferation rate, the mesenchymal stem cells are unlikely to abnormally differentiate due to the stable expression of an introduced gene because the cells can regulate the expression of TRAIL protein and CD protein therein according to treatment with or without doxycycline, and are of high stability because apoptosis is induced by 5-FC treatment to allow the removal of residual stem cells. In addition, cell lines expressing both TRAIL and CD were observed to have excellent anticancer effects. Therefore, the pharmaceutical composition of the present invention can be effectively used for prevention or treatment of cancer.