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Substituted triazolopiperazine PARP inhibitor, preparation method therefor, and use thereof

机译:取代的三唑并哌嗪的pARP抑制剂,其制备方法及其用途

摘要

The present invention relates to a class of substituted triazolopiperazine compounds represented by general formula (I), tautomers, enantiomers, diastereomers, racemates, metabolites, metabolic precursors, and pharmaceutically acceptable salts, esters, prodrugs or hydrates thereof, a preparation method therefor, intermediates, and a use thereof in the preparation of drugs for the prevention and treatment of PARP-related disorders, wherein said PARP-related disorders comprise various ischemic diseases, neurodegenerative disorders and cancer.
机译:本发明涉及由通式(I)表示的一类取代的三唑并哌嗪化合物,互变异构体,对映异构体,非对映异构体,外消旋体,代谢产物,代谢前体及其药学上可接受的盐,酯,前药或水合物,其制备方法,中间体以及其在制备用于预防和治疗PARP相关疾病的药物中的用途,其中所述PARP相关疾病包括各种缺血性疾病,神经退行性疾病和癌症。

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