Provided are an NF-κB specific activation gene expression vector and an application thereof. The gene expression vector comprises the two elements of a promoter sequence that regulates gene expression and a promoter downstream effector gene encoding sequence; the promoter sequence consists of an NF-κB response sequence and a minimal promoter sequence. After the gene expression vector is introduced into an NF-κB over-activated cell, the effector gene on the vector is expressed by the activation of the sequence-specific transcription factor NF-κB, and the effector gene generates effects on cell physiology, such as cell growth inhibition, apoptosis, death, and so on. The gene expression vector may be used for the preparation of gene therapy agents and drugs for treating diseases associated with NF-κB over-activation.
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