RECOMBINANT MUTANTα1-ANTITRYPSIN AND PREPARATION AND APPLICATION THEREOF

摘要

Provided is an α1-antitrypsin mutant, which is an active F51L/M351V/M358V triple mutant and/or a chemical modifier thereof. Further provided is a method for preparing the α1-antitrypsin mutant, a pharmaceutical composition or a kit comprising the α1-antitrypsin mutant and an application of the α1-antitrypsin mutant in the preparation of a drug for treating lung disease.