COMPOSITION FOR SUPPRESSING AUTOPHAGY IN CELLS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR PREVENTING OR TREATING NEOPLASTIC DISEASES OR SUPPRESSING ANTICANCER DRUG RESISTANCE

摘要

The present invention relates to a polypeptide having inhibitory activity on autophagy in cells, and a composition comprising the same as an effective component for suppressing autophagy in cells, particularly tumor cells, and more specifically, to a composition for inhibiting autophagy in cells, comprising, as an effective component, a polypeptide inhibiting the mechanism regulating autophagy; and a pharmaceutical composition comprising the same for preventing or treating neoplastic diseases, or suppressing anticancer drug resistance. According to the present invention, the polypeptide according to the present invention regulates the expression of autophagy-associated proteins, p-AMPK, ATG5-ATG12, Beclin1, p-Beclin1, LC3-I, LC3-II, p-mTOR, and p62, thereby inhibiting autophagy, and thus is effective for preventing or treating neoplastic diseases, and can also suppress anticancer drug resistance.