Process for suppressing expression of vcam-1 Process for suppressing expression of redox-sensitive gene Process for activating gene progress prediction or evaluation of diseases mediated by vcma-1 in vivo Process for predicting evaluation of disease mediated by sensitive gene around in vivo process for evaluation of vascular endothelial cell sensitivity process for selecting compounds process for treating cardiovascular disease process for suppressing expression of vcam-1 in human cells process for treating inflammatory skin disease process for treating human endothelial disease process for treating condition inflammatory and pharmaceutical composition

摘要

A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.