SEGMENT FOR OLIGONUCLEOTIDE SYNTHESIS, PRODUCTION METHOD FOR SAME, AND OLIGONUCLEOTIDE SYNTHESIS METHOD USING SAME

摘要

Provided are: a segment for oligonucleotide synthesis represented by formula (I); a production method for the same; and an oligonucleotide synthesis method using the same. In the formula: B is a protected/unprotected nucleotide base; R¹ is a protective group; R², R³, and R⁴ are OCH₂CH₂CN or OCH₂CH=CH₂, for example; R⁵ is a substituted/unsubstituted aliphatic group/aromatic group; X is an unshared electron pair, O, or S; Y is NHR⁶, a halogen, or CN, for example, or a hydroxyl group protected by an acyl, ether, or silyl protective group; R⁶ is H, an aliphatic group, or an aromatic group; Z is H, an alkyl, an O- or N-alkyl, or a halogen, or together with Y forms a bond Z-Y; and the value of (m+n) is an integer of 2-23.