OPTICALLY ACTIVE SEGMENT FOR STEREOCONTROLLED OLIGONUCLEOTIDE SYNTHESIS, PRODUCTION METHOD FOR SAME, AND STEREOCONTROLLED OLIGONUCLEOTIDE SYNTHESIS METHOD USING SAME

摘要

Provided are: an optically active segment for stereocontrolled oligonucleotide synthesis represented by formula (I); a production method for the same; and a stereocontrolled oligonucleotide synthesis method using the same. (In the formula, B is a protected/unprotected nucleotide base; R¹ is substituted/unsubstituted aliphatic group; R² and R³ are a DMTr group or –P(R¹¹)(NR¹²)₂; R¹¹ is OCH₂CH₂CN or SCH₂CH₂CN, for example; R¹² is a substituted/unsubstituted aliphatic group or aromatic group; X is H, an alkyl, or an O-alkyl, for example; Y is H, NHR¹³, or a halogen, for example, or a hydroxyl group protected by an acyl, ether, or silyl protective group, or together with X forms a bond X-Y; and n is an integer of 0-4.)