ADCC Fc An Antibody Fc Variant for Enhancing ADCC Activity

摘要

The present invention relates to a polypeptide comprising an Fc domain in which a part of an amino acid sequence of the human antibody Fc domain is replaced with another amino acid sequence, or an antibody comprising the same. The Fc domain of the present invention is useful for the treatment of cancer by optimizing the Fc domain by substituting some amino acid sequences of a wild-type Fc domain with other amino acid sequences, thereby exerting excellent binding affinity to the Fc receptor and manufacturing homogenous aglycosylated antibodies through bacterial culture.