机译:在抗体的核心岩藻糖上的位点选择化学酶改性增强了其Fcγ受体亲和力和ADCC活性
Department of Chemistry and Biochemistry University of Maryland College Park Maryland 20742 United States;
Computer Aided Drug Design Center Department of Pharmaceutical Sciences School of Pharmacy University of Maryland Baltimore Maryland 21201 United States;
Department of Chemistry and Biochemistry University of Maryland College Park Maryland 20742 United States;
Laboratory of Molecular Genetics and Immunology The Rockefeller University New York 10065 United States;
Laboratory of Molecular Genetics and Immunology The Rockefeller University New York 10065 United States;
Computer Aided Drug Design Center Department of Pharmaceutical Sciences School of Pharmacy University of Maryland Baltimore Maryland 21201 United States;
Department of Chemistry and Biochemistry University of Maryland College Park Maryland 20742 United States;
Laboratory of Molecular Genetics and Immunology The Rockefeller University New York 10065 United States;
Computer Aided Drug Design Center Department of Pharmaceutical Sciences School of Pharmacy University of Maryland Baltimore Maryland 21201 United States;
Department of Chemistry and Biochemistry University of Maryland College Park Maryland 20742 United States;
机译:抗体Fc结构域的同质糖型的化学酶法合成和Fey受体结合。均分的糖部分的存在增强了Fc对FcγⅢa受体的亲和力
机译:具有增强的ADCC活性的抗人EphA3受体的高亲和力重组抗体
机译:对岩藻糖阴性抗体FcgammaRIIIa的增强结合亲和力足以诱导最大的抗体依赖性细胞毒性。
机译:使用基于报道的生物测定和工程化TNFα+和VEGF +靶细胞测量抗TNFα和抗VEGF治疗抗体的FC介导的ADCC和CDC活性的测量
机译:定义Fc-Fcγ受体相互作用在抗CD137单克隆抗体治疗的抗肿瘤功能中的作用。
机译:抗体Fc结构域均匀糖族的化学酶合成和Fcγ受体结合。分数糖部分的存在增强了Fc至FcγIIIA受体的亲和力
机译:针对amL干细胞抗原CD96的亲和力成熟和Fc工程化的微型抗体的增强的aDCC活性。
机译:HIV-1共同受体的结构和功能分析:带电残基和翻译后修饰对受体活性的影响