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METHOD FOR PREPARING MONOCLONAL ANTIBODIES WITH HIGH ADCC ACTIVITY OR HIGH INDUCTION OF CYTOKINE ACTIVITY BY SELECTION OF LOW FUCOSE CONTENT/ GALACTOSE CONTENT RATIO
METHOD FOR PREPARING MONOCLONAL ANTIBODIES WITH HIGH ADCC ACTIVITY OR HIGH INDUCTION OF CYTOKINE ACTIVITY BY SELECTION OF LOW FUCOSE CONTENT/ GALACTOSE CONTENT RATIO
The present invention relates to monoclonal antibodies with high ADCC activity, characterised in having glycannic structures with a ratio (fucose content/galactose content) of 0.6 or less on the glycosylation site thereof in the Fc region. The invention also relates to pharmaceutical compositions, containing said monoclonal antibodies with high effector activity.
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