3 - Hierarchy of epithelial-mesenchymal transition gradient in 3D spheroid Mesenchymal stromal cells

摘要

The present invention relates to the stratification of epithelial-mesenchymal transition gradients in three-dimensional mesenchymal stromal cell globules. In the present invention, it was found that the change in niche activity of mesenchymal stem cells is closely related to epithelial-mesenchymal transition. Specifically, when nich activity was enhanced by 3D intercellular interactions or related physiological stimuli, the gradient of epithelial-mesenchymal transition changed to mesenchymal state and showed the opposite trend in degenerative state due to leukemia. . Accordingly, the present invention is expected to enhance the efficacy of mesenchymal stem cell-based cell therapy by regulating or introducing epidermal-mesenchymal transition related factors.