FIELD: medicine.;SUBSTANCE: invention represents a stabilized composition possessing antiviral, anti-tumour, immunomodulatory, actoprotective, antimutagenic and antioxidant activity, which is an acid-fast capsule containing calcium stearate, aerosil, microcrystalline carboxymethylcellulose, starch, lactose, grape seed powder, mannitol and in low doses lyophilisates of human recombinant interferon gamma and tumour necrosis factor - thymosin alpha 1, with the following ratio of components, wt. %: lyophilisate of human recombinant interferon gamma with activity 10×106 IU/g 0.5–2.5, recombinant tumour necrosis factor-lyophilizate - thymosin alpha 1 with activity 10×106 UN/g 0.2–1.0, grape seed powder 20–30, calcium stearate 1.23–3.7, aerosil 0.6–1.8, microcrystalline carboxymethyl cellulose 6–14.1, starch 14.5–29.5, lactose 6–14, mannitol - balance.;EFFECT: use of the disclosed composition provides stabilizing effect of cytokines due to optimally selected composition of components and amount thereof, obtaining gamma-based human recombinant interferon and TNF-T of a stabilized composition having high anti-tumour, antiviral, antioxidant, immunomodulatory, actoprotective, antimutagenic activity, wider range of storage temperature of interferon gamma and TNF-T without loss of activity, minimal side effect.;3 cl, 1 dwg, 3 ex
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机译：技术领域本发明涉及具有抗病毒，抗肿瘤，免疫调节，活化保护，抗诱变和抗氧化活性的稳定化组合物，其是包含硬脂酸钙，气溶胶，微晶羧甲基纤维素，淀粉，乳糖，葡萄籽的耐酸胶囊。粉末，甘露醇和低剂量的人重组干扰素γ和肿瘤坏死因子-胸腺素α1的冻干物，其组成比例如下： ％：活性为10×10 6 IU / g 0.5-2.5的人重组干扰素γ的冻干物，重组肿瘤坏死因子冻干物-胸腺素α1，活性为10×10 6 UN / g 0.2–1.0，葡萄籽粉20–30，硬脂酸钙1.23–3.7，aerosil 0.6–1.8，微晶羧甲基纤维素6-11.4，淀粉14.5-29.5，乳糖6-114，甘露醇-平衡。由于最佳选择的组分组成和用量，所公开的组合物的使用提供了细胞因子的稳定作用，获得了具有高抗肿瘤，抗病毒，抗氧化剂，免疫调节，激活保护作用的稳定化组合物的基于γ的人重组干扰素和TNF-T，抗突变活性，干扰素γ和TNF-T的储存温度范围更广，且无活性损失，副作用极小。; 3 cl，1 dwg，3 ex
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