A THERAPEUTIC VACCINE FOR HEPATITIS B VIRUS (HBV) USING THE HBV PRES1 AND/OR PRES2, AND/OR S-HBSAG REGIONS OF THE HBV ENVELOPE PROTEIN

摘要

Compositions including a CD180 binding ligand and a linked Hepatitis B antigen and their use are disclosed. The Hepatitis B antigen includes Hepatitis B virus pre-S1 and/or pre-S2 region of the HBV envelope protein (HBVpreS1/S2Ag), L-HBsAg, MHBsAg, S-HBsAg, or antigenic fragments or mutants thereof.