PRIORITIZATION OF GENETIC MODIFICATIONS TO INCREASE THROUGHPUT OF PHENOTYPIC OPTIMIZATION

摘要

Systems, methods and computer-readable media are provided for determining modifications to apply to genes within at least one microbial strain to improve phenotypic performance. The disclosure teaches accessing first phenotypic performance data based at least in part upon first gene modifications made to a first set of genes in at least one microbial strain; predicting second phenotypic performance of second gene modifications, based at least in part upon the first phenotypic performance data and at least one modification feature that is common to the first gene modifications and the second gene modifications; and prioritizing the second gene modifications to be applied to a second set of genes based at least in part upon the second phenotypic performance.