Prioritization of genetic modifications to increase throughput of phenotypic optimization

摘要

Systems, methods, and computer readable media are provided for determining modifications to apply to genes in one or more microbial strains to improve phenotypic performance. The present invention includes accessing first phenotypic performance data based at least in part on a first genetic modification made in a first set of genes in at least one microbial strain; Predicting a second phenotype performance of the second genetic modification based at least in part on the first phenotypic performance data and at least one modification characteristic common to the first and second genetic modifications; And prioritizing the second genetic modification to be applied to the second genetic modification based at least in part on the second phenotypic performance.