Prioritization of genetic modification to increase phenotypic optimization throughput

摘要

A system, method and computer-readable medium for determining modifications to improve phenotypic performance by applying to genes in at least one microbial strain. The present disclosure provides access to first phenotypic performance data, at least in part, based on first genetic modification performed on the first gene set in at least one phenotypic strain; first phenotype. Predicting a second predictive phenotypic performance of a second genetic modification, at least partially based on performance data and at least one modification feature common to the first and second genetic modification; It also teaches prioritizing the second genetic modification to be applied to the second set of genes, at least in part, based on the second phenotypic performance.