Systems and methods for demand and supply forecasting for clinical trials are disclosed. An embodiment of a computer-implemented method may include receiving, by a server from a user, one or more electronic files that contain parameters of a clinical trial, the parameters comprising a quantity of patients, a plurality of sites, and one or more confidence values, calculating, by the server, according to the quantity of patients, a respective demand profile for each of the plurality of sites, calculating, by the server, according to the one or more confidence values, a buffer quantity for each of the plurality of sites, calculating, by the server, a supply plan for the clinical trial according to the demand profiles and the buffer quantities, and transmitting, by the server, the supply plan to the user.
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