Anti-MET antibody, bispecific antigen-binding molecule binding to MET, and method of using the same

摘要

Provided herein are antibodies and bispecific antigen binding molecules that bind to MET and methods of using the same. The bispecific antigen-binding molecule comprises a first antigen-binding domain and a second antigen-binding domain, wherein the first antigen-binding domain and the second antigen-binding domain are two different human extracellular domains of MET. Binds to an (preferably non-overlapping) epitope. Bispecific antigen binding molecules can block the interaction between human MET and its ligand HGF. A bispecific antigen binding molecule, for example, as compared to a monovalent antigen binding molecule comprising only one of the antigen binding domains of the bispecific molecule, which is prone to exert unwanted MET agonist activity. Can show minimal MET agonist activity or no MET agonist activity.