Single nucleotide polymorphisms of the APOE promoter associated with the risk of Alzheimer's disease and uses thereof

摘要

The present invention relates to single nucleotide polymorphisms (SNPs) that can be used to predict the risk of Alzheimer's disease. The SNP is rs405509, and the human genome map GRCh38. Located on chromosome 19, 4490579, based on p7. The present invention suggests that the rs405509 T allele plays a role in further increasing the risk of APOE E4 / E4 dementia. The results of the comparison of cerebral cortical thickness and hippocampal volume between APOE genotypes suggest that E4 / E4 contractions are greater than E3 / E3 in Asians. The cerebral cortex of Caucasians with the E4 / E4 genotype and those with the rs405509 T / T genotype is more severely atrophied. Accordingly, the present invention allows the confirmation of the rs405509 T / T polymorphism with APOE E4 / E4, thereby being used to diagnose or predict Alzheimer's disease and / or dementia due to Alzheimer's disease. You can