HLA class I deficient NK-92 cells with reduced immunogenicity

摘要

Modified NK-92 cells containing genetic alterations that reduce the expression of β2 microglobulin (B2M) in NK-92 cells to reduce the level of HLA class I expression; methods for making such cells; and B2M Described herein are methods for treating a subject having, for example, cancer, using the modified NK-92 cells.