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HLA CLASS I-DEFICIENT NK-92 CELLS WITH DECREASED IMMUNOGENICITY
HLA CLASS I-DEFICIENT NK-92 CELLS WITH DECREASED IMMUNOGENICITY
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机译:HLA I型缺乏免疫原性的NK-92细胞
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摘要
Described herein are modified NK-92 cells comprising a genetic alteration to decrease beta-2-microglobulin (B2M) expression in NK-92 cells to reduce the levels of HLA class I expression; methods of generating such cells; and methods of treating a subject, e.g., that has cancer, with the B2M-modified NK-92 cells.
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