HLA class I-deficient NK-92 cells with reduced immunogenicity

摘要

Modified NK-92 cells containing a genetic alteration that reduces the level of HLA class I expression by reducing beta-2-microglobulin (B2M) expression in NK-92 cells; A method for producing such cells; And methods of treating a subject with cancer, for example, with B2M-modified NK-92 cells, are described herein.