首页> 外国专利> POLYPEPTIDE EPITOPES OF S. AUREUS AND RESPECTIVE MONOCLONAL ANTIBODIES FOR THE TREATMENT OF INFECTIONS AND IMMUNE-DIAGNOSIS

POLYPEPTIDE EPITOPES OF S. AUREUS AND RESPECTIVE MONOCLONAL ANTIBODIES FOR THE TREATMENT OF INFECTIONS AND IMMUNE-DIAGNOSIS

机译：金黄色葡萄球菌多肽表位和相应的单克隆抗体用于感染和免疫诊断

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摘要

The present invention relates to pharmaceutical preparations for the treatment or the prevention of a Staphylococcal infection. They contain at least one polypeptide epitope, wherein said at least one polypeptide epitope induces protective antibodies in a patient in need thereof. The polypeptide epitopes according to the present invention can preferably be used for the preparation of a vaccine against a Staphylococcal infection, such as Staphylococcus aureus, including Staphylococcus aureus (MRSA). The present invention further relates to monoclonal antibodies capable of recognizing and binding to a polypeptide epitope according to the present invention, and the invention also relates to the use of the monoclonal antibodies for diagnosis and the prevention or therapy Staphylococcal infection, including MRSA.

机译：本发明涉及用于治疗或预防葡萄球菌感染的药物制剂。它们包含至少一种多肽表位，其中所述至少一种多肽表位在需要其的患者中诱导保护性抗体。根据本发明的多肽表位可优选用于制备抗葡萄球菌感染的疫苗，例如金黄色葡萄球菌，包括金黄色葡萄球菌（MRSA）。本发明进一步涉及能够识别并结合根据本发明的多肽表位的单克隆抗体，并且本发明还涉及该单克隆抗体在诊断和预防或治疗葡萄球菌感染（包括MRSA）中的用途。 展开▼

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公开/公告号US2020113992A1

专利类型

公开/公告日2020-04-16

原文格式PDF

申请/专利权人 ALEXANDER KLIMKA;OLEG KRUT;MARTIN KRÖNKE;
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申请/专利号US201816486937

发明设计人 ALEXANDER KLIMKA;OLEG KRUT;MARTIN KRÖNKE;
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申请日2018-02-16

分类号A61K39/085;C07K14/31;C07K16/12;A61P31/04;

国家 US

入库时间 2022-08-21 11:25:57

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2. PBP2-a蛋白的单克隆抗体和同源序列用于由厚壁菌门的细菌引起的免疫诊断和感染的处理 [P] . 中国专利： CN102741281A . 2012-10-17

3. POLYPEPTIDE EPITOPES OF S. AUREUS AND RESPECTIVE MONOCLONAL ANTIBODIES FOR THE TREATMENT OF INFECTIONS AND IMMUNE-DIAGNOSIS [P] . 欧洲知识产权局专利： EP3582807A1 . 2019-12-25

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机译：金黄色葡萄球菌多肽表位和相应的单克隆抗体用于感染和免疫诊断

5. POLYPEPTIDE EPITOPES OF S. AUREUS AND RESPECTIVE MONOCLONAL ANTIBODIES FOR THE TREATMENT OF INFECTIONS AND IMMUNE-DIAGNOSIS [P] . 欧洲知识产权局专利： EP3363459A1 . 2018-08-22

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