Development of a Monoclonal Antibody Therapeutic for the Prevention and Treatment of Pseudomonas aeruginosa Infection

摘要

Unlike conventional vaccine formulations, peptide vaccines are able to target the immune system to specific neutralizing or otherwise protective epitopes. Despite this, there are no peptide vaccines approved for use in humans. In the development of a peptide vaccine, selection and design of the peptide immunogen is critical for generating antibodies that are cross-reactive with the cognate protein of interest.